Synthesis and Molecular Docking Analysis of New Thiazo-isoindolinedione Hybrids as Potential Inhibitors of the SARS-CoV-2 Main Protease

Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from reaction thiazolidinedione and isoindoline-dione. The structures compounds were elucidated by 1H-, 13C-NMR, MS analyses. Furthermore, molecular docking analysis was performed study potential inhibition SARS-CoV-2 main protease (Mpro) new thiazo-isoindolinediones. present revealed that thiazo-isoindolinediones could inhibit Mpro represent a promising platform for experimental development antiviral drugs based on scaffolds.